Issue 32, 2018
From the journal:

Chemical Communications

Regioselectivity inversion tuned by iron(iii) salts in palladium-catalyzed carbonylations†

Zijun Huang,ab   Yazhe Cheng,a   Xipeng Chen,a   Hui-Fang Wang,*c   Chen-Xia Dud  and  Yuehui Li ORCID logo *a  

* Corresponding authors

a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, P. R. China
E-mail: yhli@licp.cas.cn

b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

c State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China
E-mail: wanghf@suda.edu.cn

d College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China

Abstract

Impactful regioselectivity control is crucial for cost-effective chemical synthesis. By using cheap and abundant iron(III) salts, the hydroxycarbonylations of both aromatic and aliphatic alkenes were significantly enhanced in both reactivity and selectivity (iso/n or n/iso up to >99 : 1). Moreover, Pd-catalyzed carbonylation selectivity can be switched from branched to linear by using different Fe(III) salts. In addition, similar results were obtained for the carbonylation of secondary alcohols.

Graphical abstract: Regioselectivity inversion tuned by iron(iii) salts in palladium-catalyzed carbonylations

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Article information

DOI
https://doi.org/10.1039/C8CC01190G
Article type
Communication
Submitted
10 Feb 2018
Accepted
21 Mar 2018
First published
22 Mar 2018

Chem. Commun., 2018,54, 3967-3970

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Regioselectivity inversion tuned by iron(III) salts in palladium-catalyzed carbonylations

Z. Huang, Y. Cheng, X. Chen, H. Wang, C. Du and Y. Li, Chem. Commun., 2018, 54, 3967 DOI: 10.1039/C8CC01190G

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