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Cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes via cyano migration: synthesis of trifluoromethylthiolated acrylonitriles

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Abstract

Herein a novel, elusive cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes is reported. Taking advantage of the intramolecular cyano migration strategy, the reaction proceeds stereoselectively to deliver E-olefinic products. A variety of tetrasubstituted trifluoromethylthiolated acrylonitriles are afforded in modest to good yields.

Graphical abstract: Cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes via cyano migration: synthesis of trifluoromethylthiolated acrylonitriles

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Publication details

The article was received on 10 Feb 2018, accepted on 20 Mar 2018 and first published on 20 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01189C
Citation: Chem. Commun., 2018, Advance Article
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    Cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes via cyano migration: synthesis of trifluoromethylthiolated acrylonitriles

    M. Ji, J. Yu and C. Zhu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC01189C

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