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Issue 37, 2018
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Modulating the physical properties of solid forms of urea using co-crystallization technology

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Abstract

The solid-form landscape of urea was explored using full interaction maps (FIMs) and data from the CSD to develop optimum protocols for synthesizing co-crystals of urea. As a result, 49 of the 60 attempted reactions produced new co-crystals, and the crystal structures of four of these are presented. Moreover, the goal of reducing the solubility and lowering the hygroscopicity of the parent compound was achieved, which in turn offers new opportunities for application as a slow-release fertilizer with limited hygroscopicity, thereby reducing many current problems of transport, handling, and storage of urea.

Graphical abstract: Modulating the physical properties of solid forms of urea using co-crystallization technology

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Publication details

The article was received on 09 Feb 2018, accepted on 12 Mar 2018 and first published on 22 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC01144C
Citation: Chem. Commun., 2018,54, 4657-4660
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    Modulating the physical properties of solid forms of urea using co-crystallization technology

    B. Sandhu, A. S. Sinha, J. Desper and C. B. Aakeröy, Chem. Commun., 2018, 54, 4657
    DOI: 10.1039/C8CC01144C

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