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Issue 36, 2018
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Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells

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Abstract

Size-dependent uptake behaviors of electrically neutral amphipathic polymeric nanoparticles in cell-sized liposomes and living cells were investigated. Kinetic analyses and the particle size distribution suggested a size-dependent penetration mechanism (size threshold: 3.1 nm). The definite size-dependent uptake provides a new insight into the interactions between nanomaterials and living cells.

Graphical abstract: Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells

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The article was received on 04 Feb 2018, accepted on 27 Mar 2018 and first published on 04 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC00977E
Citation: Chem. Commun., 2018,54, 4557-4560
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    Size-dependent uptake of electrically neutral amphipathic polymeric nanoparticles by cell-sized liposomes and an insight into their internalization mechanism in living cells

    S. Ichikawa, N. Shimokawa, M. Takagi, Y. Kitayama and T. Takeuchi, Chem. Commun., 2018, 54, 4557
    DOI: 10.1039/C8CC00977E

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