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Issue 25, 2018
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A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy

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Abstract

Gene therapy with small interfering RNA (siRNA) has been proved to be a promising technology to treat various diseases by hampering the production of target proteins. However, developing a delivery system that has high efficiency in transporting siRNA without obvious side effects remains a challenge. Herein, we designed a new survivin siRNA delivery system based on polyethyleneimine functionalized black phosphorus (BP) nanosheets which could suppress tumor growth by silencing survivin expression. Combined with the photothermal properties of the BP nanosheets, the presented delivery system shows excellent therapy efficiency for tumors. Therefore, the BP-based delivery system would be a promising tool for future clinical applications.

Graphical abstract: A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy

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Publication details

The article was received on 02 Feb 2018, accepted on 01 Mar 2018 and first published on 02 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC00931G
Citation: Chem. Commun., 2018,54, 3142-3145
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    A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy

    H. Wang, L. Zhong, Y. Liu, X. Xu, C. Xing, M. Wang, S. Bai, C. Lu and H. Yang, Chem. Commun., 2018, 54, 3142
    DOI: 10.1039/C8CC00931G

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