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A selective glucose sensor: the cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

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Abstract

Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.

Graphical abstract: A selective glucose sensor: the cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

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Publication details

The article was received on 02 Feb 2018, accepted on 06 Apr 2018 and first published on 09 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC00914G
Citation: Chem. Commun., 2018, Advance Article
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    A selective glucose sensor: the cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

    C. Tsai, Y. Tang, H. Chen, Y. Yao, T. Chien and C. Kao, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00914G

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