Issue 26, 2018

Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants

Abstract

We present a novel strategy for the discrimination of single nucleotide variants (SNVs) by combining cooperativity with sequestration, which displays remarkably high specificity (discrimination factors ranging from 67 to 618 with a median of 194) against 12 model SNVs and can be easily integrated with PCR amplification to detect KRAS G12D mutation.

Graphical abstract: Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants

Supplementary files

Article information

Article type
Communication
Submitted
31 Jan 2018
Accepted
02 Mar 2018
First published
02 Mar 2018

Chem. Commun., 2018,54, 3223-3226

Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants

S. Hu, N. Li and F. Liu, Chem. Commun., 2018, 54, 3223 DOI: 10.1039/C8CC00838H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements