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A headgroup linker perturbs pKa via acyl chain migration: designing base-labile supramolecular assemblies

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Abstract

Acyl chain transfer, which perturbs the protonation equilibrium of amine and reduces the apparent pKa by 2.0–2.5 units, is used to develop a liposome-based drug delivery system.

Graphical abstract: A headgroup linker perturbs pKa via acyl chain migration: designing base-labile supramolecular assemblies

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Publication details

The article was received on 29 Jan 2018, accepted on 28 Mar 2018 and first published on 29 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC00776D
Citation: Chem. Commun., 2018, Advance Article
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    A headgroup linker perturbs pKa via acyl chain migration: designing base-labile supramolecular assemblies

    A. Sardar, N. K. Rout, S. Nath, M. Prasad, J. Mahanti, S. Mondal and P. K. Tarafdar, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00776D

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