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Issue 45, 2018
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Pressure and cosolvent modulation of the catalytic activity of amyloid fibrils

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Abstract

We report on the effects of pressure and cosolvents on the catalytic activity of a designed amyloid fibril by applying a high-pressure stopped-flow methodology with rapid spectroscopic detection. FTIR spectroscopic data revealed a remarkable pressure and temperature stability of the fibrillar catalyst. The activity is further enhanced by osmolytes and macromolecular crowding.

Graphical abstract: Pressure and cosolvent modulation of the catalytic activity of amyloid fibrils

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Publication details

The article was received on 26 Jan 2018, accepted on 17 Apr 2018 and first published on 17 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC00699G
Citation: Chem. Commun., 2018,54, 5696-5699
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    Pressure and cosolvent modulation of the catalytic activity of amyloid fibrils

    M. W. Jaworek, V. Schuabb and R. Winter, Chem. Commun., 2018, 54, 5696
    DOI: 10.1039/C8CC00699G

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