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A 18F radiolabelled Zn(II) sensing fluorescent probe

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A selective fluorescent probe for Zn(II), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(II) ([AQA-F] = 0.1 mM, [Zn(II)Cl2] = 0–300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ = 35% is also observed. AQA-F has a binding constant, Kd = 15.2 μM with Zn(II). This probe has been shown to respond to endogenous Zn(II) levels in vitro in prostate and prostate cancer cell lines. [18F]AQA-F has been synthesized with a radiochemical yield of 8.6% and a radiochemical purity of 97% in 88 minutes. AQA-F shows the potential for a dual modal PET/fluorescence imaging probe for Zn(II).

Graphical abstract: A 18F radiolabelled Zn(ii) sensing fluorescent probe

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The article was received on 26 Jan 2018, accepted on 05 Mar 2018 and first published on 05 Mar 2018

Article type: Communication
DOI: 10.1039/C8CC00687C
Citation: Chem. Commun., 2018, Advance Article
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    A 18F radiolabelled Zn(II) sensing fluorescent probe

    T. W. Price, G. Firth, C. J. Eling, M. Kinnon, N. J. Long, J. Sturge and G. J. Stasiuk, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00687C

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