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Issue 27, 2018
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Regioselective synthesis of unsymmetrical biheteroaryls via copper(II)-catalyzed cascade annulation

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Abstract

A facile and efficient copper-catalyzed cascade annulation of an imidazoheterocycle with salicylaldehyde, piperidine, and terminal alkyne was developed to afford unsymmetrical biheteroaryl derivatives. A variety of biheteroaryl structural motifs containing furans and imidazoheterocycles have been synthesized in ambient air in high yields. The experimental results suggest that the reaction proceeds through a sequential non-radical 5-exo-dig cyclization process.

Graphical abstract: Regioselective synthesis of unsymmetrical biheteroaryls via copper(ii)-catalyzed cascade annulation

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Publication details

The article was received on 26 Jan 2018, accepted on 06 Mar 2018 and first published on 08 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC00671G
Citation: Chem. Commun., 2018,54, 3379-3382
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    Regioselective synthesis of unsymmetrical biheteroaryls via copper(II)-catalyzed cascade annulation

    S. Samanta and A. Hajra, Chem. Commun., 2018, 54, 3379
    DOI: 10.1039/C8CC00671G

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