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Issue 16, 2018
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Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy

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Abstract

We report that carbonate esters could turn hydrophobic camptothecin (CPT)-unsaturated fatty acid prodrugs into nanoaggregates in aqueous solution. The active CPT could be rapidly released once triggered by a reductive stimulus when a carbonate ester was combined with a disulfide bond, resulting in a potent in vivo antitumor activity.

Graphical abstract: Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy

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Publication details

The article was received on 25 Jan 2018, accepted on 29 Jan 2018 and first published on 29 Jan 2018


Article type: Communication
DOI: 10.1039/C8CC00639C
Citation: Chem. Commun., 2018,54, 1996-1999
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    Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy

    Y. Li, T. Kang, Y. Wu, Y. Chen, J. Zhu and M. Gou, Chem. Commun., 2018, 54, 1996
    DOI: 10.1039/C8CC00639C

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