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Zinc-ion-mediated self-assembly of forky peptides for prostate cancer-specific drug delivery

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Abstract

A novel forky peptide was designed and synthesized. The peptide self-assembled into supramolecular hydrogels triggered by zinc ions (ZIs). The hydrogels were designed for a drug delivery system (DDS), loaded with docetaxel and applied for the therapy of prostate cancer. In this research, we have discussed the response mechanism and evaluated the anticancer effect of the DDS.

Graphical abstract: Zinc-ion-mediated self-assembly of forky peptides for prostate cancer-specific drug delivery

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Publication details

The article was received on 24 Jan 2018, accepted on 09 Apr 2018 and first published on 10 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC00604K
Citation: Chem. Commun., 2018, Advance Article
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    Zinc-ion-mediated self-assembly of forky peptides for prostate cancer-specific drug delivery

    M. Tao, K. Xu, S. He, H. Li, L. Zhang, X. Luo and W. Zhong, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00604K

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