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Enantioselective aza-Friedel–Crafts reaction of cyclic ketimines with indoles using chiral imidazoline–phosphoric acid catalysts

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Abstract

An enantioselective aza-Friedel Crafts reaction of cyclic 4-aryl-3-oxo-1,2,5-thiadiazol-1,1-oxides as cyclic ketimines with indoles was developed. High enantioselectivities were observed for the reaction of various cyclic ketimines with indoles using chiral imidazoline–phosphoric acid catalysts. The obtained products can be converted to chiral α-amino amide and hydantoin.

Graphical abstract: Enantioselective aza-Friedel–Crafts reaction of cyclic ketimines with indoles using chiral imidazoline–phosphoric acid catalysts

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Publication details

The article was received on 24 Jan 2018, accepted on 09 Feb 2018 and first published on 09 Feb 2018


Article type: Communication
DOI: 10.1039/C8CC00594J
Citation: Chem. Commun., 2018, Advance Article
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    Enantioselective aza-Friedel–Crafts reaction of cyclic ketimines with indoles using chiral imidazoline–phosphoric acid catalysts

    S. Nakamura, T. Furukawa, T. Hatanaka and Y. Funahashi, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00594J

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