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A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature

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Abstract

A chiral aluminum solvating agent (CASA) was demonstrated to be a general and efficient reagent for 1H NMR chiral analysis of alcohols. The sodium salt of the CASA (CASA-Na) showed a complete baseline peak separation of the hydroxyl group for various chiral alcohols including primary, secondary, and tertiary alcohols with alkyl and aryl substituents in CD3CN. Due to the weak intermolecular interaction, 1H NMR measurement at low temperature (−40 to 10 °C) was required.

Graphical abstract: A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature

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Publication details

The article was received on 23 Jan 2018, accepted on 05 Mar 2018 and first published on 06 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC00574E
Citation: Chem. Commun., 2018, Advance Article
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    A chiral aluminum solvating agent (CASA) for 1H NMR chiral analysis of alcohols at low temperature

    M. Seo, S. Jang and H. Kim, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00574E

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