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Issue 34, 2018
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[18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling

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Abstract

Operationally simple radiosynthesis and purification of [18F]fluoro-benziodoxole was developed starting from a cyclotron produced [18F]F precursor, [18F]TBAF, and tosyl-benziodoxole. The synthetic utility of [18F]fluoro-benziodoxole was demonstrated by electrophilic fluorocyclization of o-styrilamides proceeding with high RCC (typically 50–90%) and high molar activity (up to 396 GBq μmol−1).

Graphical abstract: [18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling

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Publication details

The article was received on 22 Jan 2018, accepted on 03 Apr 2018 and first published on 03 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC00526E
Citation: Chem. Commun., 2018,54, 4286-4289
  • Open access: Creative Commons BY-NC license
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    [18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling

    M. A. Cortés González, P. Nordeman, A. Bermejo Gómez, D. N. Meyer, G. Antoni, M. Schou and K. J. Szabó, Chem. Commun., 2018, 54, 4286
    DOI: 10.1039/C8CC00526E

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