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Issue 23, 2018
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Copper-catalyzed synthesis of α-amino nitriles through methyl transfer from DMF to aromatic amines

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Abstract

A copper-catalyzed activation of C(sp3)–H bonds of DMF at room temperature was developed, which results in methyl transfer to aromatic amines for efficient synthesis of exceedingly valuable α-amino nitriles. This process features excellent functional group tolerance, a broad substrate scope, and high activity under ambient conditions.

Graphical abstract: Copper-catalyzed synthesis of α-amino nitriles through methyl transfer from DMF to aromatic amines

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Publication details

The article was received on 20 Jan 2018, accepted on 13 Feb 2018 and first published on 13 Feb 2018


Article type: Communication
DOI: 10.1039/C8CC00485D
Citation: Chem. Commun., 2018,54, 2854-2857
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    Copper-catalyzed synthesis of α-amino nitriles through methyl transfer from DMF to aromatic amines

    Z. Yuan, N. Li, C. Zhu and C. Xia, Chem. Commun., 2018, 54, 2854
    DOI: 10.1039/C8CC00485D

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