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Issue 28, 2018
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pH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system

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Abstract

Herein, a class of pH-responsive spherical nucleic acid (SNA) nanostructures prepared by functionalizing gold nanoparticles with DNA nanodevices is presented, which can perform duplex-to-triplex transition upon pH change via pH-sensitive parallel Hoogsteen interactions. The SNA nanostructures exhibit tunable pH sensitivity and a highly rapid and reversible allosteric effect. Furthermore, they can exactly image lysosomes in living cells. We next engineered pH-triggered doxorubicin(Dox)–SNA conjugates that could deliver Dox molecules into cancer cells and achieve pH-dependent drug release.

Graphical abstract: pH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system

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Publication details

The article was received on 18 Jan 2018, accepted on 07 Mar 2018 and first published on 08 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC00440D
Citation: Chem. Commun., 2018,54, 3520-3523
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    pH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system

    H. Li, X. Zhou, D. Yao and H. Liang, Chem. Commun., 2018, 54, 3520
    DOI: 10.1039/C8CC00440D

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