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Issue 24, 2018
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Modulating the rigidity of nanoparticles for tumor penetration

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Abstract

How the rigidity of nanoparticles affects their penetration into tumors is unclear. Core–shell nanoparticles were prepared with amphipathic poly(ethylene glycol)-b-(poly ε-caprolactone-g-poly butyl acrylate) (PEG–(PCL-g-PBA)) so that the mechanical stiffness of their cores could be varied in order to test the relationship between their rigidity and penetration through tumors. The rigidity of the nanoparticles was adjusted by the changeable crystallinity of the core, which was altered by varying the ratio of ε-caprolactone and butyl acrylate.

Graphical abstract: Modulating the rigidity of nanoparticles for tumor penetration

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Publication details

The article was received on 17 Jan 2018, accepted on 22 Feb 2018 and first published on 23 Feb 2018


Article type: Communication
DOI: 10.1039/C8CC00398J
Citation: Chem. Commun., 2018,54, 3014-3017
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    Modulating the rigidity of nanoparticles for tumor penetration

    H. Deng, K. Song, J. Zhang, L. Deng, A. Dong and Z. Qin, Chem. Commun., 2018, 54, 3014
    DOI: 10.1039/C8CC00398J

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