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Issue 16, 2018
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Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation

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Abstract

We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Subsequent evaluations showed that B19 could selectively bind to and stabilize the c-myc promoter i-motif without significant binding to the G-quadruplex and duplex DNA. This caused down-regulation of c-myc transcription and expression, resulting in tumor cell apoptosis.

Graphical abstract: Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation

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Publication details

The article was received on 15 Jan 2018, accepted on 30 Jan 2018 and first published on 30 Jan 2018


Article type: Communication
DOI: 10.1039/C8CC00328A
Citation: Chem. Commun., 2018,54, 2036-2039
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    Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation

    B. Shu, J. Cao, G. Kuang, J. Qiu, M. Zhang, Y. Zhang, M. Wang, X. Li, S. Kang, T. Ou, J. Tan, Z. Huang and D. Li, Chem. Commun., 2018, 54, 2036
    DOI: 10.1039/C8CC00328A

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