Jump to main content
Jump to site search


Silver-mediated direct C–H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents

Author affiliations

Abstract

A highly efficient direct C–H amination of BODIPYs has been accomplished through the Ag(I)-mediated nucleophilic addition of an amino radical to BODIPY at the C3- and/or C5-position and deprotonation processes under mild conditions. This protocol greatly streamlines the access to a variety of 3-aminated and 3,5-diaminated BODIPYs. The resulting BODIPYs with morpholine groups (3q and 4b) exhibit specific endoplasmic reticulum (ER)-localization capacities and negligible cytotoxicities, which would be potential ER-targeting reagents.

Graphical abstract: Silver-mediated direct C–H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Jan 2018, accepted on 13 Feb 2018 and first published on 13 Feb 2018


Article type: Communication
DOI: 10.1039/C8CC00238J
Citation: Chem. Commun., 2018, Advance Article
  •   Request permissions

    Silver-mediated direct C–H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents

    H. Zhang, X. Chen, J. Lan, Y. Liu, F. Zhou, D. Wu and J. You, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00238J

Search articles by author

Spotlight

Advertisements