Issue 26, 2018

Silver-mediated direct C–H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents

Abstract

A highly efficient direct C–H amination of BODIPYs has been accomplished through the Ag(I)-mediated nucleophilic addition of an amino radical to BODIPY at the C3- and/or C5-position and deprotonation processes under mild conditions. This protocol greatly streamlines the access to a variety of 3-aminated and 3,5-diaminated BODIPYs. The resulting BODIPYs with morpholine groups (3q and 4b) exhibit specific endoplasmic reticulum (ER)-localization capacities and negligible cytotoxicities, which would be potential ER-targeting reagents.

Graphical abstract: Silver-mediated direct C–H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2018
Accepted
13 Feb 2018
First published
13 Feb 2018

Chem. Commun., 2018,54, 3219-3222

Silver-mediated direct C–H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents

H. Zhang, X. Chen, J. Lan, Y. Liu, F. Zhou, D. Wu and J. You, Chem. Commun., 2018, 54, 3219 DOI: 10.1039/C8CC00238J

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