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Silver-mediated direct C−H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents

Abstract

A highly efficient direct C−H amination of BODIPYs has been accomplished through the Ag(I)-mediated nucleophilic addition of amino radical to BODIPY at the C3 and/or C5-position and deprotonation processes under mild conditions. This protocol greatly streamlines access to a variety of 3-aminated and 3,5-diaminated BODIPYs. The resulting BODIPYs with morpholine groups (3q and 4b) exhibit specific endoplasmic reticulum (ER)-localization capacities and negligible cytotoxicities, which would be potential ER-targeting reagents.

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Publication details

The article was received on 11 Jan 2018, accepted on 13 Feb 2018 and first published on 13 Feb 2018


Article type: Communication
DOI: 10.1039/C8CC00238J
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Silver-mediated direct C−H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents

    H. Zhang, X. Chen, J. Lan, Y. Liu, F. Zhou, D. Wu and J. You, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC00238J

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