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Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

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Abstract

Efficient formation of water- and air-stable aza-ylides has been achieved using the Staudinger reaction between electron-deficient aromatic azides such as 2,6-dichlorophenyl azide and triarylphosphines. The reaction proceeds rapidly and has been successfully applied to chemical modification of proteins in living cells.

Graphical abstract: Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

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Publication details

The article was received on 09 Jan 2018, accepted on 13 May 2018 and first published on 14 May 2018


Article type: Communication
DOI: 10.1039/C8CC00179K
Citation: Chem. Commun., 2018, Advance Article
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    Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

    T. Meguro, N. Terashima, H. Ito, Y. Koike, I. Kii, S. Yoshida and T. Hosoya, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00179K

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