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Real-time monitoring of the aggregation of Alzheimer's amyloid-β via 1H magic angle spinning NMR spectroscopy

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Abstract

Proton magic-angle-spinning NMR used for real-time analysis of amyloid aggregation reveals that mechanical rotation of Aβ1–40 monomers increases the rate of formation of aggregates, and that the increasing lag-time with peptide concentration suggests the formation of growth-incompetent species. EGCG's ability to shift off-pathway aggregation is also demonstrated.

Graphical abstract: Real-time monitoring of the aggregation of Alzheimer's amyloid-β via 1H magic angle spinning NMR spectroscopy

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Publication details

The article was received on 08 Jan 2018, accepted on 31 Jan 2018 and first published on 31 Jan 2018


Article type: Communication
DOI: 10.1039/C8CC00167G
Citation: Chem. Commun., 2018, Advance Article
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    Real-time monitoring of the aggregation of Alzheimer's amyloid-β via 1H magic angle spinning NMR spectroscopy

    J. Wang, T. Yamamoto, J. Bai, S. J. Cox, K. J. Korshavn, M. Monette and A. Ramamoorthy, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00167G

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