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Issue 26, 2018
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Lewis-base-catalysed selective reductions of ynones with a mild hydride donor

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Abstract

Ynones are efficiently reduced with a mild hydride donor in the presence of a catalytic amount of nucleophilic phosphines. The reactions are selective 1,2-reductions that give propargyl alcohols in yields of up to 96%. It is proposed that success in these reactions depends on the activation of ynones by a Lewis base catalyst. A protic additive plays a key role in suppressing the undesired reaction pathways and accelerating the 1,2-reductions.

Graphical abstract: Lewis-base-catalysed selective reductions of ynones with a mild hydride donor

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Publication details

The article was received on 04 Jan 2018, accepted on 01 Mar 2018 and first published on 02 Mar 2018


Article type: Communication
DOI: 10.1039/C8CC00058A
Citation: Chem. Commun., 2018,54, 3266-3269
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    Lewis-base-catalysed selective reductions of ynones with a mild hydride donor

    F. Schömberg, Y. Zi and I. Vilotijevic, Chem. Commun., 2018, 54, 3266
    DOI: 10.1039/C8CC00058A

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