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Polar organometallic strategies for regioselective C–H metallation of N-heterocyclic carbenes

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Abstract

N-Heterocyclic carbenes (NHCs) have become indispensable ligands across a broad swathe of the synthetic and catalytic landscape, not in small part due to their ease of electronic and steric tunability. One of the latest additions to this important family of ligands are anionic NHCs, which have become valuable precursors to access abnormal NHC complexes as well as shown great potential for further NHC functionalisation. Deprotonative metallation has emerged as one of the most versatile methodologies to access anionic NHCs, where judicious choice of reaction conditions and metallating agents can finely tune the regioselectivity of the reaction. This Feature Article focuses on the recent emergence of s-block metal-mediated NHC metallations and the new opportunities this methodology offers.

Graphical abstract: Polar organometallic strategies for regioselective C–H metallation of N-heterocyclic carbenes

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Publication details

The article was received on 03 Jan 2018, accepted on 23 Jan 2018 and first published on 23 Jan 2018


Article type: Feature Article
DOI: 10.1039/C8CC00049B
Citation: Chem. Commun., 2018, Advance Article
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    Polar organometallic strategies for regioselective C–H metallation of N-heterocyclic carbenes

    M. Uzelac and E. Hevia, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC00049B

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