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Issue 16, 2018
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Stereoselective synthesis of a Podophyllum lignan core by intramolecular reductive nickel-catalysis

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Abstract

A Ni-catalyzed reductive cascade to a diastereocontrolled construction of THN[2,3-c]furan, is developed. The mild reaction conditions led to the tolerance of broad functional groups that can be placed in almost every position of this skeleton with good yields. The conformational control for the observed trans- or cis-fused selectivity during this tandem cyclization-coupling is also proposed.

Graphical abstract: Stereoselective synthesis of a Podophyllum lignan core by intramolecular reductive nickel-catalysis

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Publication details

The article was received on 01 Jan 2018, accepted on 29 Jan 2018 and first published on 07 Feb 2018


Article type: Communication
DOI: 10.1039/C8CC00001H
Citation: Chem. Commun., 2018,54, 2040-2043
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    Stereoselective synthesis of a Podophyllum lignan core by intramolecular reductive nickel-catalysis

    J. Xiao, X. Cong, G. Yang, Y. Wang and Y. Peng, Chem. Commun., 2018, 54, 2040
    DOI: 10.1039/C8CC00001H

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