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Cooperative 5- and 10-membered ring interactions in the 10-helix folding of oxetin homo-oligomers

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Abstract

Homo-oligomers of the natural product oxetin (cis-3-amino-2-oxetanecarboxylic acid) were prepared and their conformational behaviour studied in solution and solid state and by molecular modelling. The predominant secondary structure was a 10-helix, propiciously stabilized by a network of 5-membered ring H-bonds implicating ring oxygens and neighboring amide hydrogen atoms.

Graphical abstract: Cooperative 5- and 10-membered ring interactions in the 10-helix folding of oxetin homo-oligomers

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Publication details

The article was received on 31 Dec 2017, accepted on 30 Jan 2018 and first published on 30 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09964A
Citation: Chem. Commun., 2018, Advance Article
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    Cooperative 5- and 10-membered ring interactions in the 10-helix folding of oxetin homo-oligomers

    S. S. Ragab, A. F. Kassir, R. Guillot, M. Scherrmann, T. Boddaert and D. J. Aitken, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC09964A

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