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Copper-Catalyzed Decarboxylative Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles

Abstract

A copper-catalyzed decarboxylative regioselective protocol for the synthesis of 1,5-disubstituted 1,2,3-triazoles through direct annulation of cinnamic acids with aryl azides has been developed. This is the first example of 1,5-disubstituted 1,2,3-triazoles, under aerobic condition using Cu (II) as the catalyst, which was generally synthesized by ruthenium (II) catalyst. The operational simplicity and regioselectivity of this methodology, complementing to the classical CuAAC catalyzed the synthesis of 1,4-disubstituted 1,2,3-triazoles.

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Publication details

The article was received on 29 Dec 2017, accepted on 09 Feb 2018 and first published on 14 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09934G
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Copper-Catalyzed Decarboxylative Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles

    A. Kumar, N. Kumar, M. Y. Ansari and R. Kant, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C7CC09934G

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