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Issue 21, 2018
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Copper-catalyzed decarboxylative regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles

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Abstract

A copper-catalyzed decarboxylative regioselective protocol for the synthesis of 1,5-disubstituted 1,2,3-triazoles through direct annulation of cinnamic acids with aryl azides has been developed. This is the first example of 1,5-disubstituted 1,2,3-triazoles, under aerobic conditions using Cu(II) as the catalyst, which were generally synthesized using a ruthenium(II) catalyst. The simplicity and regioselectivity of this methodology, complementing to the classical CuAAC catalyzed the synthesis of 1,4-disubstituted 1,2,3-triazoles.

Graphical abstract: Copper-catalyzed decarboxylative regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles

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Publication details

The article was received on 29 Dec 2017, accepted on 09 Feb 2018 and first published on 14 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09934G
Citation: Chem. Commun., 2018,54, 2627-2630
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    Copper-catalyzed decarboxylative regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles

    N. Kumar, M. Y. Ansari, R. Kant and A. Kumar, Chem. Commun., 2018, 54, 2627
    DOI: 10.1039/C7CC09934G

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