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Issue 26, 2018
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Melting proteins confined in nanodroplets with 10.6 μm light provides clues about early steps of denaturation

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Abstract

Ubiquitin confined within nanodroplets was irradiated with a variable-power CO2 laser. Mass spectrometry analysis shows evidence for a protein “melting”-like transition within droplets prior to solvent evaporation and ion formation. Ion mobility spectrometry reveals that structures associated with early steps of denaturation are trapped because of short droplet lifetimes.

Graphical abstract: Melting proteins confined in nanodroplets with 10.6 μm light provides clues about early steps of denaturation

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Publication details

The article was received on 23 Dec 2017, accepted on 08 Mar 2018 and first published on 08 Mar 2018


Article type: Communication
DOI: 10.1039/C7CC09829D
Citation: Chem. Commun., 2018,54, 3270-3273
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    Melting proteins confined in nanodroplets with 10.6 μm light provides clues about early steps of denaturation

    T. J. El-Baba, D. R. Fuller, D. W. Woodall, S. A. Raab, C. R. Conant, J. M. Dilger, Y. Toker, E. R. Williams, D. H. Russell and D. E. Clemmer, Chem. Commun., 2018, 54, 3270
    DOI: 10.1039/C7CC09829D

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