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Glucuronic acid as a helix-inducing linker in short peptides

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Abstract

A new strategy is demonstrated for making peptides helical, using a carbohydrate to bridge between sidechains at each end of a pentapeptide. CD and NMR spectra establish that both an α-helix and a 310-helix structure can form depending upon the bridge.

Graphical abstract: Glucuronic acid as a helix-inducing linker in short peptides

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Publication details

The article was received on 22 Dec 2017, accepted on 06 Feb 2018 and first published on 06 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09785A
Citation: Chem. Commun., 2018, Advance Article
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    Glucuronic acid as a helix-inducing linker in short peptides

    C. Wu, H. N. Hoang, L. Liu and D. P. Fairlie, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC09785A

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