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Nickel-catalyzed C–O bond reduction of aryl and benzyl 2-pyridyl ethers

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Abstract

The reduction of aryl and benzyl 2-pyridyl ethers with sodium isopropoxide was carried out via nickel-catalyzed C–OPy bond cleavage, giving reductive products in reasonable to excellent yields. This method allowed the 2-pyridyloxy group to be directly removed with high efficiency, mild reaction conditions, and good compatibility of functional groups.

Graphical abstract: Nickel-catalyzed C–O bond reduction of aryl and benzyl 2-pyridyl ethers

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Publication details

The article was received on 18 Dec 2017, accepted on 01 Feb 2018 and first published on 01 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09668B
Citation: Chem. Commun., 2018, Advance Article
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    Nickel-catalyzed C–O bond reduction of aryl and benzyl 2-pyridyl ethers

    J. Li and Z. Wang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC09668B

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