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Issue 19, 2018
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Spatially resolved coding of λ-orthogonal hydrogels by laser lithography

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Abstract

A λ-orthogonal reaction system is introduced, where visible light induced radical thiol–ene and UV light induced NITEC (Nitrile-Imine mediated Tetrazole–Ene Conjugation) ligations are consecutively employed to fabricate and functionalize PEG-based hydrogels. The fluorescent pyrazoline cycloadducts from the NITEC reaction are exploited to visualize the written structures within the hydrogels as well as to attach RGD containing functional groups to promote spatially resolved cell attachment on the hydrogel surface.

Graphical abstract: Spatially resolved coding of λ-orthogonal hydrogels by laser lithography

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Publication details

The article was received on 15 Dec 2017, accepted on 07 Feb 2018 and first published on 19 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09619D
Citation: Chem. Commun., 2018,54, 2436-2439
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    Spatially resolved coding of λ-orthogonal hydrogels by laser lithography

    R. R. Batchelor, E. Blasco, K. N. R. Wuest, H. Lu, M. Wegener, C. Barner-Kowollik and M. H. Stenzel, Chem. Commun., 2018, 54, 2436
    DOI: 10.1039/C7CC09619D

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