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Issue 20, 2018
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Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly

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Abstract

A flowerlike nanovector is developed for the fluorescence imaging and detection of miRNA in live cells with catalytic hairpin assembly. This horned vector provides a high loading efficiency of DNA amplifiers for multiple signal outputs and is applied to detect miRNA-21 in an average single HeLa cell, showing promising application in trace detection of intracellular biomolecules.

Graphical abstract: Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly

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Publication details

The article was received on 14 Dec 2017, accepted on 12 Feb 2018 and first published on 12 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09579A
Citation: Chem. Commun., 2018,54, 2550-2553
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    Sensitive detection of intracellular microRNA based on a flowerlike vector with catalytic hairpin assembly

    J. Liu, P. Du, J. Zhang, H. Shen and J. Lei, Chem. Commun., 2018, 54, 2550
    DOI: 10.1039/C7CC09579A

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