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Sensitive detection of intracellular microRNA based on flowerlike vector with catalytic hairpin assembly

Abstract

A flowerlike nanovector is developed for fluorescence imaging and detection of miRNA in live cells with catalytic hairpin assembly. This horned vector provides a highly efficient loading of DNA amplifiers for multiple signal outputs and is applied in detection of miRNA-21 in an average single HeLa cell, showing the promising applications in trace detection of intracellular biomolecules.

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Publication details

The article was received on 14 Dec 2017, accepted on 12 Feb 2018 and first published on 12 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09579A
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Sensitive detection of intracellular microRNA based on flowerlike vector with catalytic hairpin assembly

    J. Liu, P. Du, J. Zhang, H. Shen and J. Lei, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C7CC09579A

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