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Issue 21, 2018
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Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

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Abstract

An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C–C/C–N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.

Graphical abstract: Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

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Publication details

The article was received on 14 Dec 2017, accepted on 01 Feb 2018 and first published on 01 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09571F
Citation: Chem. Commun., 2018,54, 2615-2618
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    Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

    X. Chu, B. Cheng, Y. Zhang, D. Ge, Z. Shen and T. Loh, Chem. Commun., 2018, 54, 2615
    DOI: 10.1039/C7CC09571F

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