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In situ formation of large pore silica–MnO2 nanocomposites with H+/H2O2 sensitivity for O2-elevated photodynamic therapy and potential MR imaging

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Abstract

A cancer cell-specific, endogenous H+/H2O2-activated, and O2 self-sufficient nanocomposite is engineered and characterized. Such NPs, with good biocompatibility and rapid response to intracellular H+/H2O2, have demonstrated improved therapeutic effects in targeted cancer cells and activated MR signals in vitro, providing a promising strategy for effective PDT against tumor hypoxia.

Graphical abstract: In situ formation of large pore silica–MnO2 nanocomposites with H+/H2O2 sensitivity for O2-elevated photodynamic therapy and potential MR imaging

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Publication details

The article was received on 13 Dec 2017, accepted on 24 Jan 2018 and first published on 24 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09532E
Citation: Chem. Commun., 2018, Advance Article
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    In situ formation of large pore silica–MnO2 nanocomposites with H+/H2O2 sensitivity for O2-elevated photodynamic therapy and potential MR imaging

    Z. He, Y. Xiao, J. Zhang, P. Zhang and J. Zhu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC09532E

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