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Issue 23, 2018
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Facile meltPEGylation of flame-made luminescent Tb3+-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica

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Abstract

Flame aerosol technology is a versatile method for scalable synthesis of nanoparticles. Since particles are produced and collected in a dry state, dispersibility and further functionalization could pose hurdles to their biomedical use. We report on a one-pot, scalable and robust procedure for the PEGylation of flame-made yttria and silica nanoparticles. We demonstrate improved colloidal stability, attenuated activation of blood coagulation and decreased uptake into phagocytic cells, all of which pave the way for facilitated biomedical use of flame-made oxide nanoparticles.

Graphical abstract: Facile meltPEGylation of flame-made luminescent Tb3+-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica

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Publication details

The article was received on 07 Dec 2017, accepted on 19 Feb 2018 and first published on 19 Feb 2018


Article type: Communication
DOI: 10.1039/C7CC09402G
Citation: Chem. Commun., 2018,54, 2914-2917
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    Facile meltPEGylation of flame-made luminescent Tb3+-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica

    K. Keevend, G. Panzarasa, F. H. L. Starsich, M. Zeltner, A. Spyrogianni, E. Tsolaki, G. Fortunato, S. E. Pratsinis, S. Bertazzo and I. K. Herrmann, Chem. Commun., 2018, 54, 2914
    DOI: 10.1039/C7CC09402G

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