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Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

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Abstract

Tetrahedral DNA nanostructures (TDNs) have gathered great attention and are being widely used in biomedicine. We demonstrated that autophagy increased after exposure to TDNs (250 nM) along with the up-regulation of several autophagy-related genes and proteins. TDNs enhanced cell autophagy through the PI3K/AKT/mTOR signaling pathway.

Graphical abstract: Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

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Publication details

The article was received on 07 Dec 2017, accepted on 02 Jan 2018 and first published on 02 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09397G
Citation: Chem. Commun., 2018, Advance Article
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    Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

    S. Shi, S. Lin, Y. Li, T. Zhang, X. Shao, T. Tian, T. Zhou, Q. Li and Y. Lin, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC09397G

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