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Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells

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Abstract

The rhodium(III) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.

Graphical abstract: Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells

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Publication details

The article was received on 07 Dec 2017, accepted on 16 Jan 2018 and first published on 16 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09384E
Citation: Chem. Commun., 2018, Advance Article
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    Identification of a rhodium(III) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells

    G. Yang, H. Zhong, C. Ko, S. Wong, K. Vellaisamy, M. Ye, D. Ma and C. Leung, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC09384E

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