Issue 6, 2018

Amplified detection of genome-containing biological targets using terminal deoxynucleotidyl transferase-assisted rolling circle amplification

Abstract

We proposed a terminal deoxynucleotidyl transferase (TdT)-assisted rolling circle amplification (RCA) strategy for the amplified detection of genome-containing biological targets. The synergetic signal amplification of DNase I-mediated genomic DNA fragmentation and subsequent RCA allow the sensing platform to have extraordinarily high sensitivity.

Graphical abstract: Amplified detection of genome-containing biological targets using terminal deoxynucleotidyl transferase-assisted rolling circle amplification

Supplementary files

Article information

Article type
Communication
Submitted
05 Dec 2017
Accepted
19 Dec 2017
First published
19 Dec 2017

Chem. Commun., 2018,54, 682-685

Amplified detection of genome-containing biological targets using terminal deoxynucleotidyl transferase-assisted rolling circle amplification

Y. Du, Y. Zhu, X. Li and D. Kong, Chem. Commun., 2018, 54, 682 DOI: 10.1039/C7CC09337C

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