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Issue 29, 2018
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DNA nanoclew templated spherical nucleic acids for siRNA delivery

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Abstract

A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed a DNA nanoclew (DC). After uptake by cultured cancer cells, SNA nanoparticles release engrafted siRNAs by cleavage of the intracellular Dicer enzyme. Moreover, in vitro experiments reveal that such SNAs demonstrate potent gene knockdown at both mRNA and protein levels, while with negligible cytotoxicity.

Graphical abstract: DNA nanoclew templated spherical nucleic acids for siRNA delivery

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Publication details

The article was received on 02 Dec 2017, accepted on 13 Mar 2018 and first published on 14 Mar 2018


Article type: Communication
DOI: 10.1039/C7CC09257A
Citation: Chem. Commun., 2018,54, 3609-3612
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    DNA nanoclew templated spherical nucleic acids for siRNA delivery

    W. Ruan, M. Zheng, Y. An, Y. Liu, D. B. Lovejoy, M. Hao, Y. Zou, A. Lee, S. Yang, Y. Lu, M. Morsch, R. Chung and B. Shi, Chem. Commun., 2018, 54, 3609
    DOI: 10.1039/C7CC09257A

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