Issue 10, 2018

A well-defined unimolecular channel facilitates chloride transport

Abstract

A unimolecular ion channel was optimized by functionalization with a new type of rigid-rod oligomer. The macrocycle pendant endows chloride selectivity and the fluorescence feature and suitable length of the rod facilitates the visual insertion of channels into the lipid bilayer, resulting in efficient ion transport with an EC50 value of 0.36 μM.

Graphical abstract: A well-defined unimolecular channel facilitates chloride transport

Supplementary files

Article information

Article type
Communication
Submitted
30 Nov 2017
Accepted
10 Jan 2018
First published
10 Jan 2018

Chem. Commun., 2018,54, 1249-1252

A well-defined unimolecular channel facilitates chloride transport

S. Chen, Y. Zhao, C. Bao, Y. Zhou, C. Wang, Q. Lin and L. Zhu, Chem. Commun., 2018, 54, 1249 DOI: 10.1039/C7CC09200H

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