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A well-defined unimolecular channel facilitates chloride transport

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Abstract

A unimolecular ion channel was optimized by functionalization with a new type of rigid-rod oligomer. The macrocycle pendant endows chloride selectivity and the fluorescence feature and suitable length of the rod facilitates the visual insertion of channels into the lipid bilayer, resulting in efficient ion transport with an EC50 value of 0.36 μM.

Graphical abstract: A well-defined unimolecular channel facilitates chloride transport

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Publication details

The article was received on 30 Nov 2017, accepted on 10 Jan 2018 and first published on 10 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09200H
Citation: Chem. Commun., 2018, Advance Article
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    A well-defined unimolecular channel facilitates chloride transport

    S. Chen, Y. Zhao, C. Bao, Y. Zhou, C. Wang, Q. Lin and L. Zhu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC09200H

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