Jump to main content
Jump to site search


The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates

Author affiliations

Abstract

The inverse electron-demand Diels–Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radiosynthesis of 225Ac-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothiocyanate couplings.

Graphical abstract: The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Nov 2017, accepted on 26 Jan 2018 and first published on 26 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09129J
Citation: Chem. Commun., 2018, Advance Article
  •   Request permissions

    The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates

    S. Poty, R. Membreno, J. M. Glaser, A. Ragupathi, W. W. Scholz, B. M. Zeglis and J. S. Lewis, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC09129J

Search articles by author

Spotlight

Advertisements