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Issue 21, 2018
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The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates

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Abstract

The inverse electron-demand Diels–Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radiosynthesis of 225Ac-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothiocyanate couplings.

Graphical abstract: The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates

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Publication details

The article was received on 27 Nov 2017, accepted on 26 Jan 2018 and first published on 26 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09129J
Citation: Chem. Commun., 2018,54, 2599-2602
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    The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates

    S. Poty, R. Membreno, J. M. Glaser, A. Ragupathi, W. W. Scholz, B. M. Zeglis and J. S. Lewis, Chem. Commun., 2018, 54, 2599
    DOI: 10.1039/C7CC09129J

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