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Three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds

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Abstract

This report describes a new method for three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds via air-stable SCF3 and SeCF3 reagents as free-radical initiators of ethyl iododifluoroacetate. β-Proton elimination can be overcome effectively in this reaction system, and a broad substrate scope, including alkenes and alkynes, makes this approach practical and attractive.

Graphical abstract: Three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds

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Publication details

The article was received on 26 Nov 2017, accepted on 09 Jan 2018 and first published on 09 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09083H
Citation: Chem. Commun., 2018, Advance Article
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    Three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds

    B. Zhang, L. Gao, Z. Zhang, Y. Wen and Y. Liang, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC09083H

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