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Issue 7, 2018
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Nucleophilic fluorination facilitated by a CsF–CaF2 packed bed reactor in continuous flow

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Abstract

A simple to prepare, dry and handle packed bed reactor carrying CsF on CaF2, towards nucleophilic fluorinations in continuous flow, is reported. The reactor also proved adaptable for silyl-ether deprotection and trifluoromethylations with Ruppert's reagent. The study includes reactor stability and scale-up investigations.

Graphical abstract: Nucleophilic fluorination facilitated by a CsF–CaF2 packed bed reactor in continuous flow

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Publication details

The article was received on 23 Nov 2017, accepted on 02 Jan 2018 and first published on 02 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09035H
Citation: Chem. Commun., 2018,54, 825-828
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    Nucleophilic fluorination facilitated by a CsF–CaF2 packed bed reactor in continuous flow

    M. B. Johansen and A. T. Lindhardt, Chem. Commun., 2018, 54, 825
    DOI: 10.1039/C7CC09035H

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