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Issue 6, 2018
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Copper/guanidine-catalyzed asymmetric alkynylation of isatin-derived ketimines

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Abstract

Isatin-derived ketimines undergo enantioselective alkynylation reactions in the presence of copper iodide and easily accessible guanidine-amides. The corresponding 3-alkynyl-3-aminooxyindoles are obtained in up to 95% yield and 96% ee. The guanidine plays a role in the formation of copper acetylide and the enantiodetermining step and the basic additive is excluded.

Graphical abstract: Copper/guanidine-catalyzed asymmetric alkynylation of isatin-derived ketimines

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Publication details

The article was received on 20 Nov 2017, accepted on 19 Dec 2017 and first published on 19 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08920A
Citation: Chem. Commun., 2018,54, 678-681
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    Copper/guanidine-catalyzed asymmetric alkynylation of isatin-derived ketimines

    Q. Chen, L. Xie, Z. Li, Y. Tang, P. Zhao, L. Lin, X. Feng and X. Liu, Chem. Commun., 2018, 54, 678
    DOI: 10.1039/C7CC08920A

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