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Issue 11, 2018
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Chemical decontamination of iPS cell-derived neural cell mixtures

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Abstract

This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.

Graphical abstract: Chemical decontamination of iPS cell-derived neural cell mixtures

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Publication details

The article was received on 13 Nov 2017, accepted on 12 Jan 2018 and first published on 12 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08686E
Citation: Chem. Commun., 2018,54, 1355-1358
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    Chemical decontamination of iPS cell-derived neural cell mixtures

    D. Mao, X. K. W. Chung, T. Andoh-Noda, Y. Qin, S. Sato, Y. Takemoto, W. Akamatsu, H. Okano and M. Uesugi, Chem. Commun., 2018, 54, 1355
    DOI: 10.1039/C7CC08686E

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