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Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

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Abstract

The expedient synthesis of compounds enriched in sp3 character is key goal in modern drug discovery. Herein, we report how a single pot Suzuki–Miyaura-hydrogenation can be used to furnish lead and fragment-like products in good to excellent yields. The approach has been successfully applied in formats amenable to parallel synthesis, in an asymmetric sense, and in the preparation of molecules with annotated biological activity.

Graphical abstract: Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

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Publication details

The article was received on 10 Nov 2017, accepted on 27 Nov 2017 and first published on 27 Nov 2017


Article type: Communication
DOI: 10.1039/C7CC08670A
Citation: Chem. Commun., 2018, Advance Article
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    Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

    P. S. Campbell, C. Jamieson, I. Simpson and A. J. B. Watson, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08670A

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