Issue 11, 2018

Albusnodin: an acetylated lasso peptide from Streptomyces albus

Abstract

We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.

Graphical abstract: Albusnodin: an acetylated lasso peptide from Streptomyces albus

Supplementary files

Article information

Article type
Communication
Submitted
08 Nov 2017
Accepted
10 Jan 2018
First published
10 Jan 2018

Chem. Commun., 2018,54, 1339-1342

Albusnodin: an acetylated lasso peptide from Streptomyces albus

C. Zong, W. L. Cheung-Lee, H. E. Elashal, M. Raj and A. J. Link, Chem. Commun., 2018, 54, 1339 DOI: 10.1039/C7CC08620B

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