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Albusnodin: an acetylated lasso peptide from Streptomyces albus

Abstract

We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.

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Publication details

The article was accepted on 10 Jan 2018 and first published on 10 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08620B
Citation: Chem. Commun., 2018, Accepted Manuscript
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    Albusnodin: an acetylated lasso peptide from Streptomyces albus

    C. Zong, W. L. Cheung-Lee, H. E. Elashal, M. Raj and A. J. Link, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C7CC08620B

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