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Issue 11, 2018
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Albusnodin: an acetylated lasso peptide from Streptomyces albus

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Abstract

We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.

Graphical abstract: Albusnodin: an acetylated lasso peptide from Streptomyces albus

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Publication details

The article was received on 08 Nov 2017, accepted on 10 Jan 2018 and first published on 10 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08620B
Citation: Chem. Commun., 2018,54, 1339-1342
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    Albusnodin: an acetylated lasso peptide from Streptomyces albus

    C. Zong, W. L. Cheung-Lee, H. E. Elashal, M. Raj and A. J. Link, Chem. Commun., 2018, 54, 1339
    DOI: 10.1039/C7CC08620B

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