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Synthesis of 2,5-disubstituted oxazoles via cobalt(III)-catalyzed cross-coupling of N-pivaloyloxyamides and alkynes

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Abstract

An efficient synthesis of 2,5-disubstituted oxazoles via Co(III) catalysis is described herein. The synthesis is achieved under mild conditions through [3+2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.

Graphical abstract: Synthesis of 2,5-disubstituted oxazoles via cobalt(iii)-catalyzed cross-coupling of N-pivaloyloxyamides and alkynes

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Publication details

The article was received on 08 Nov 2017, accepted on 08 Jan 2018 and first published on 08 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC08611C
Citation: Chem. Commun., 2018, Advance Article
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    Synthesis of 2,5-disubstituted oxazoles via cobalt(III)-catalyzed cross-coupling of N-pivaloyloxyamides and alkynes

    X. Yu, K. Chen, Q. Wang, W. Zhang and J. Zhu, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C7CC08611C

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