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Herein, we describe a new method for the conjugation of azide-containing target compounds that can be readily released as amines by irradiation with near UV light. This concept is based on a two-step protocol employing the chemoselective CuAAC and Staudinger-phosphonite reactions to deliver photo-cleavable phosphonamidate conjugates in high yields starting from 2-nitrobenzyl substituted phosphonites.
K. D. Siebertz and C. P. R. Hackenberger, Chem. Commun., 2018, 54, 763 DOI: 10.1039/C7CC08605A
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