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Issue 7, 2018
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Chemoselective triazole-phosphonamidate conjugates suitable for photorelease

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Abstract

Herein, we describe a new method for the conjugation of azide-containing target compounds that can be readily released as amines by irradiation with near UV light. This concept is based on a two-step protocol employing the chemoselective CuAAC and Staudinger-phosphonite reactions to deliver photo-cleavable phosphonamidate conjugates in high yields starting from 2-nitrobenzyl substituted phosphonites.

Graphical abstract: Chemoselective triazole-phosphonamidate conjugates suitable for photorelease

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Publication details

The article was received on 08 Nov 2017, accepted on 13 Dec 2017 and first published on 14 Dec 2017


Article type: Communication
DOI: 10.1039/C7CC08605A
Citation: Chem. Commun., 2018,54, 763-766
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    Chemoselective triazole-phosphonamidate conjugates suitable for photorelease

    K. D. Siebertz and C. P. R. Hackenberger, Chem. Commun., 2018, 54, 763
    DOI: 10.1039/C7CC08605A

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